Matthew K Iyer, MD, PhD
Clinical Assistant Professor of Surgery
Clinical Assistant Professor of Pathology
Rogel Cancer Center
5303 Rogel Cancer Center
Ann Arbor, MI 48109-5940

Available to mentor
Matthew K Iyer, MD, PhD
Clinical Assistant Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • About

    I am a Clinical Assistant Professor of Surgery and Pathology at the University of Michigan, and I care for patients at the University of Michigan hospital as well as the Ann Arbor VA Healthcare System. I conduct research in the areas of computational biology, bioinformatics, and data science. My long-term goal is to learn how we can use high-throughput molecular data such as DNA and RNA sequencing to improve our care of patients with cancer.

    Qualifications
    • Fellow, Complex General Surgical Oncology
      Duke University Health System, Surgery, 2023
    • Fellow, HPB Surgery
      Duke University Health System, Surgery, 2023
    • Resident, General Surgery
      Weill Cornell Medicine, Surgery, 2021
    • PhD
      University of Michigan–Ann Arbor, Ann Arbor, 2016
    • MD
      University of Michigan Medical School, Ann Arbor, 2016
    • MS Electrical Engineering
      University of Colorado Boulder, Boulder, 2006
    • BA Music
      University of Colorado Boulder, Boulder, 2003
    • BS Electrical and Computer Engineering
      University of Colorado Boulder, Boulder, 2003
    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Center for Computational Medicine and Bioinformatics
    Research Overview

    - Development of blood, urine and other biofluid tests to detect and monitor cancer
    - Investigating tumor biology using RNA-Seq, single-cell RNA-Seq, spatial transcriptomics datasets
    - Curation of a compendium of over 100,000 RNA-Seq datasets for general use in cancer research

    Recent Publications See All Publications
    • Preprint
      Spatial Transcriptomics of IPMN Reveals Divergent Indolent and Malignant Lineages.
      Iyer MK, Fletcher A, Shi C, Chen F, Kanu E, Eckhoff AM, Bao M, Frankel TL, Chinnaiyan AM, Nussbaum DP, Allen PJ. 2024 Nov 3; DOI:10.1101/2024.10.29.620810
      PMID: 39554015
    • Journal Article
      Comprehensive Assessment of the Intrinsic Pancreatic Microbiome.
      Eckhoff AM, Fletcher AA, Kelly MS, Dohlman A, McIntyre CA, Shen X, Iyer MK, Nussbaum DP, Allen PJ. Ann Surg, 2024 Apr 16; DOI:10.1097/SLA.0000000000006299
      PMID: 38623754
    • Journal Article
      ASO Visual Abstract: Timing of Adjuvant Immunotherapy in Stage III Melanoma, Does It Matter?
      Rhodin KE, Jung S-H, Elleson K, DePalo D, Straker R, McKinley S, Beekman K, Parker L, Chen S, Iyer MK, Salama AKS, Bartlett E, Karakousis G, Zager JS, Tyler DS, Beasley GM. Ann Surg Oncol, 2023 Oct; 30 (11): 6355 - 6356. DOI:10.1245/s10434-023-14089-9
      PMID: 37574517
    • Journal Article
      Timing of Adjuvant Immunotherapy in Stage III Melanoma, Does it Matter?
      Rhodin KE, Jung S-H, Elleson K, DePalo D, Straker R, McKinley S, Beekman K, Parker L, Chen S, Iyer MK, Salama AKS, Bartlett E, Karakousis G, Zager JS, Tyler DS, Beasley GM. Annals of Surgical Oncology, 2023 Oct; 30 (11): 6340 - 6352. DOI:10.1245/s10434-023-13935-0
    • Journal Article
      Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA.
      Hosono Y, Niknafs YS, Prensner JR, Iyer MK, Dhanasekaran SM, Mehra R, Pitchiaya S, Tien J, Escara-Wilke J, Poliakov A, Chu S-C, Saleh S, Sankar K, Su F, Guo S, Qiao Y, Freier SM, Bui H-H, Cao X, Malik R, Johnson TM, Beer DG, Feng FY, Zhou W, Chinnaiyan AM. Cell, 2023 Sep 14; 186 (19): 4254 - 4255. DOI:10.1016/j.cell.2023.08.025
      PMID: 37714137
    • Preprint
      Comprehensive Assessment of the Intrinsic Pancreatic Microbiome
      Eckhoff A, Fletcher A, Kelly M, Dohlman A, McIntyre C, Shen X, Iyer M, Nussbaum D, Allen P. 2023 bioRxiv, DOI:10.1101/2023.08.12.553074
    • Journal Article
      Digital spatial profiling of intraductal papillary mucinous neoplasms: Toward a molecular framework for risk stratification.
      Iyer MK, Shi C, Eckhoff AM, Fletcher A, Nussbaum DP, Allen PJ. Sci Adv, 2023 Mar 15; 9 (11): eade4582 DOI:10.1126/sciadv.ade4582
      PMID: 36930707
    • Proceeding / Abstract / Poster
      A Conserved Gene Signature Correlates with Melanoma Treatment Response in Patient Tumors and Blood
      Iyer MK, Beasley GM, Rhodin KE, Hollander S. ANNALS OF SURGICAL ONCOLOGY, 2023 30 (SUPPL 1): S150 - S150.