Available to mentor
Toshi received his B.S. from Osaka University, Japan, and his Ph.D. in Life Sciences from the University of Tokyo for studies on the metabolic regulation of macrophages with Dr. Motoharu Seiki at the Institute of Medical Science, the University of Tokyo. He was trained as a molecular biologist. He then joined the laboratory of Dr. Inder Verma, later of Dr. Tony Hunter, at the Salk Institute for Biological Studies, La Jolla. He initiated his postdoctoral work on intratumoral heterogeneity in glioblastoma by combining a mouse model of glioma with lineage tracing approaches, including lentiviral barcoding for single-cell RNA-seq in collaboration with Dr. Aviv Regev at the Broad Institute of MIT and Harvard. In 2019, he then, as a research fellow, joined Dr. Mario Suva’s laboratory in the Department of Pathology at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), and the Broad Institute. His postdoctoral studies delineated cellular states and plasticity in human glioblastoma and uncovered their molecular and cellular determinants. Working with clinical fellows and computational scientists, Toshi identified the joy of collaboration and the power of diverse perspectives in a team.
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Research FellowHarvard Medical School, Broad Institute of Harvard & MIT, 2023
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Research AssociateSalk Institute for Biological Studies, La Jolla, 2019
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Postdoctoral FellowUniversity of Tokyo, Tokyo, 2013
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Ph.D.University of Tokyo, Tokyo, 2013
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M.S.University of Tokyo Hospital, Tokyo, 2010
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B.S.Osaka University, Osaka, 2008
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Center MemberBiointerfaces Institute
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Center MemberRogel Cancer Center
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Center MemberCenter for Computational Medicine and Bioinformatics
Measuring molecular and cellular heterogeneity in human cancers using genomics platforms. Integrating genetic and genomics tools into cell and animal model systems to study human cancers. Dissecting and engineering cell-to-cell interactions of brain tumor ecosystems
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Mangena V, Chanoch-Myers R, Sartore R, Paulsen B, Gritsch S, Weisman H, Hara T, Breakefield XO, Breyne K, Regev A, Chung K, Arlotta P, Tirosh I, Suva ML. Cancer Discov, 2024 Oct 7;Journal ArticleGlioblastoma-cortical organoids recapitulate cell state heterogeneity and intercellular transfer.
DOI:10.1158/2159-8290.CD-23-1336 PMID: 39373549 -
Schiffman JS, D'Avino AR, Prieto T, Pang Y, Fan Y, Rajagopalan S, Potenski C, Hara T, Suvà ML, Gawad C, Landau DA. Nat Genet, 2024 Oct; 56 (10): 2174 - 2184.Journal ArticleDefining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution.
DOI:10.1038/s41588-024-01920-6 PMID: 39317739 -
Takahashi M, Chong HB, Zhang S, Yang T-Y, Lazarov MJ, Harry S, Maynard M, Hilbert B, White RD, Murrey HE, Tsou C-C, Vordermark K, Assaad J, Gohar M, Dürr BR, Richter M, Patel H, Kryukov G, Brooijmans N, Alghali ASO, Rubio K, Villanueva A, Zhang J, Ge M, Makram F, Griesshaber H, Harrison D, Koglin A-S, Ojeda S, Karakyriakou B, Healy A, Popoola G, Rachmin I, Khandelwal N, Neil JR, Tien P-C, Chen N, Hosp T, van den Ouweland S, Hara T, Bussema L, Dong R, Shi L, Rasmussen MQ, Domingues AC, Lawless A, Fang J, Yoda S, Nguyen LP, Reeves SM, Wakefield FN, Acker A, Clark SE, Dubash T, Kastanos J, Oh E, Fisher DE, Maheswaran S, Haber DA, Boland GM, Sade-Feldman M, Jenkins RW, Hata AN, Bardeesy NM, Suvà ML, Martin BR, Liau BB, Ott CJ, Rivera MN, Lawrence MS, Bar-Peled L. Cell, 2024 May 9; 187 (10): 2536 - 2556.e30.Journal ArticleDrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
DOI:10.1016/j.cell.2024.03.027 PMID: 38653237 -
Hara T, Chanoch-Myers R, Bussema L, Greenwald A, Behnan J, Wakimoto H, Galli R, Tirosh I, Suva M. Neuro-Oncology, 2023 Nov 10; 25 (Supplement_5): v169 - v169.Journal ArticlePATH-11. POOLED IN VIVO ASSAY TO CHARACTERIZE GLIOBLASTOMA INVASION AT THE SINGLE-CELL RESOLUTION
DOI:10.1093/neuonc/noad179.0641 -
Chen D, Varanasi SK, Hara T, Traina K, Sun M, McDonald B, Farsakoglu Y, Clanton J, Xu S, Garcia-Rivera L, Mann TH, Du V, Chung HK, Xu Z, Tripple V, Casillas E, Ma S, O'Connor C, Yang Q, Zheng Y, Hunter T, Lemke G, Kaech SM. Immunity, 2023 Sep 12; 56 (9): 2086 - 2104.e8.Journal ArticleCTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma.
DOI:10.1016/j.immuni.2023.07.015 PMID: 37572655 -
Gavish A, Tyler M, Greenwald AC, Hoefflin R, Simkin D, Tschernichovsky R, Galili Darnell N, Somech E, Barbolin C, Antman T, Kovarsky D, Barrett T, Gonzalez Castro LN, Halder D, Chanoch-Myers R, Laffy J, Mints M, Wider A, Tal R, Spitzer A, Hara T, Raitses-Gurevich M, Stossel C, Golan T, Tirosh A, Suvà ML, Puram SV, Tirosh I. Nature, 2023 Jun; 618 (7965): 598 - 606.Journal ArticleHallmarks of transcriptional intratumour heterogeneity across a thousand tumours.
DOI:10.1038/s41586-023-06130-4 PMID: 37258682 -
Hara T, Chanoch-Myers R, Greenwald A, Bussema L, Behnan J, Galli R, Wakimoto H, Tirosh I, Suvà M. Cancer Research, 2023 Apr 4; 83 (7_Supplement): 1246 - 1246.Journal ArticleAbstract 1246: Single-cell profiles of multiplexed in vivo models facilitate the characterization of phenotypic plasticity and invasion in glioblastoma
DOI:10.1158/1538-7445.am2023-1246 -
Schiffman JS, D’Avino AR, Prieto T, Pang Y, Fan Y, Rajagopalan S, Potenski C, Hara T, Suvà ML, Gawad C, Landau DA. bioRxiv,PreprintDefining ancestry, heritability and plasticity of cellular phenotypes in somatic evolution
DOI:10.1101/2022.12.28.522128
