Research INvestigator
Surgery
[email protected]
Available to mentor
Jiali Yu
Research Investigator
Jiali Yu, PhD, is a Research Investigator in the Department of Surgery at the University of Michigan since 2023.
Dr. Yu received his PhD degree at the University of Science and Technology of China in 2017. After that, he joined Dr. Weiping Zou's research laboratory at the University of Michigan as a research fellow in 2018. In 2023, Dr. Yu became a research faculty member in the Department of Surgery.
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Research FellowUniversity of Michigan Medical School, Surgery, 2023
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PhDUniversity of Science and Technology of China, Hefei, 2017
Dr. Yu’s research focuses on dissecting immune regulatory mechanisms in the tumor microenvironment (TME), aiming to identify key pathways that can be targeted to improve the efficacy of cancer immunotherapy. He has identified immunosuppressive macrophages in the liver metastatic TME mediate the therapeutic resistance to immunotherapy and radiotherapy targeting liver metastasis can synergize with immunotherapy (Nature Medicine, 2021; Cell Reports, 2022).
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Choi JE, Qiao Y, Kryczek I, Yu J, Gurkan J, Bao Y, Gondal M, Tien JC-Y, Maj T, Yazdani S, Parolia A, Xia H, Zhou J, Wei S, Grove S, Vatan L, Lin H, Li G, Zheng Y, Zhang Y, Cao X, Su F, Wang R, He T, Cieslik M, Green MD, Zou W, Chinnaiyan AM. Nat Commun, 2024 Jun 28; 15 (1): 5487Journal ArticlePIKfyve, expressed by CD11c-positive cells, controls tumor immunity.
DOI:10.1038/s41467-024-48931-9 PMID: 38942798 -
Yu J, Yan Y, Li S, Xu Y, Parolia A, Rizvi S, Wang W, Zhai Y, Xiao R, Li X, Liao P, Zhou J, Okla K, Lin H, Lin X, Grove S, Wei S, Vatan L, Hu J, Szumilo J, Kotarski J, Freeman ZT, Skala S, Wicha M, Cho KR, Chinnaiyan AM, Schon S, Wen F, Kryczek I, Wang S, Chen L, Zou W. Cell, 2024 Aug 22; 187 (17): 4713 - 4732.e19.Journal ArticleProgestogen-driven B7-H4 contributes to onco-fetal immune tolerance.
DOI:10.1016/j.cell.2024.06.012 PMID: 38968937 -
Lo BC, Kryczek I, Yu J, Vatan L, Caruso R, Matsumoto M, Sato Y, Shaw MH, Inohara N, Xie Y, Lei YL, Zou W, Núñez G. Science, 2024 Jan 5; 383 (6678): 62 - 70.Journal ArticleMicrobiota-dependent activation of CD4+ T cells induces CTLA-4 blockade-associated colitis via Fcγ receptors.
DOI:10.1126/science.adh8342 PMID: 38175892 -
Bao Y, Qiao Y, Choi JE, Zhang Y, Mannan R, Cheng C, He T, Zheng Y, Yu J, Gondal M, Cruz G, Grove S, Cao X, Su F, Wang R, Chang Y, Kryczek I, Cieslik M, Green MD, Zou W, Chinnaiyan AM. Proc Natl Acad Sci U S A, 2023 Dec 5; 120 (49): e2314416120Journal ArticleTargeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy.
DOI:10.1073/pnas.2314416120 PMID: 38011559 -
Li S, Yu J, Huber A, Kryczek I, Wang Z, Jiang L, Li X, Du W, Li G, Wei S, Vatan L, Szeliga W, Chinnaiyan AM, Green MD, Cieslik M, Zou W. Cell Rep, 2022 Apr 5; 39 (1): 110609Journal ArticleMetabolism drives macrophage heterogeneity in the tumor microenvironment.
DOI:10.1016/j.celrep.2022.110609 PMID: 35385733 -
Lin H, Kryczek I, Li S, Green MD, Ali A, Hamasha R, Wei S, Vatan L, Szeliga W, Grove S, Li X, Li J, Wang W, Yan Y, Choi JE, Li G, Bian Y, Xu Y, Zhou J, Yu J, Xia H, Wang W, Alva A, Chinnaiyan AM, Cieslik M, Zou W. Cancer Cell, 2021 Apr 12; 39 (4): 480 - 493.e6.Journal ArticleStanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance.
DOI:10.1016/j.ccell.2020.12.023 PMID: 33513345 -
Zhou J, Kryczek I, Li S, Li X, Aguilar A, Wei S, Grove S, Vatan L, Yu J, Yan Y, Liao P, Lin H, Li J, Li G, Du W, Wang W, Lang X, Wang W, Wang S, Zou W. Nat Immunol, 2021 Apr; 22 (4): 460 - 470.Journal ArticleThe ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity.
DOI:10.1038/s41590-021-00888-3 PMID: 33767425 -
Qiao Y, Choi JE, Tien JC, Simko SA, Rajendiran T, Vo JN, Delekta AD, Wang L, Xiao L, Hodge NB, Desai P, Mendoza S, Juckette K, Xu A, Soni T, Su F, Wang R, Cao X, Yu J, Kryczek I, Wang X-M, Wang X, Siddiqui J, Wang Z, Bernard A, Fernandez-Salas E, Navone NM, Ellison SJ, Ding K, Eskelinen E-L, Heath EI, Klionsky DJ, Zou W, Chinnaiyan AM. Nat Cancer, 2021 Sep; 2: 978 - 993.Journal ArticleAutophagy Inhibition by Targeting PIKfyve Potentiates Response to Immune Checkpoint Blockade in Prostate Cancer.
DOI:10.1038/s43018-021-00237-1 PMID: 34738088
