Tristan Frum
Research Assistant Professor
Internal Medicine
[email protected]

Available to mentor
Tristan Frum
Research Assistant Professor
  • Qualifications
  • Recent Publications
    • Qualifications
    • Ph.D.
      University of California, Santa Cruz, Santa Cruz, 2014
    • B.S.
      University of Washington, Seattle, 2005
    Recent Publications See All Publications
    • Preprint
      A spatially-resolved blueprint of the developing human lung reveals a basal cell population regulated by a WNT-driven niche
      Hsu PP, Conchola AS, Frum T, Dong X, Tudrick L, Ponnusamy V, Downey MS, Wu M, Yang M, Lee Y, Niestroy E, Tsai Y-H, Wu A, Huang S, Glass IA, Merajver SD, Spence JR. 2024 Oct 3; Cold Spring Harbor Laboratory, DOI:10.1101/2024.10.01.612096
    • Journal Article
      Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential before implantation.
      Kruger RE, Frum T, Brumm AS, Hickey SL, Niakan KK, Aziz F, Shammami MA, Roberts JG, Ralston A. Development, 2024 Jun 1; 151 (11): DOI:10.1242/dev.202377
      PMID: 38752427
    • Journal Article
      Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung.
      Li J, de Melo Jorge DM, Wang W, Sun S, Frum T, Hang Y-A, Liu Y, Zhou X, Xiao J, Wang X, Spence JR, Wobus CE, Zhu H-J. J Med Chem, 2024 May 9; 67 (9): 7470 - 7486. DOI:10.1021/acs.jmedchem.4c00234
      PMID: 38690769
    • Preprint
      Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels.
      Eiken MK, Childs CJ, Brastrom LK, Frum T, Plaster EM, Shachaf O, Pfeiffer S, Levine JE, Alysandratos K-D, Kotton DN, Spence JR, Loebel C. 2024 Mar 19; DOI:10.1101/2024.03.19.585720
      PMID: 38562781
    • Preprint
      Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential prior to implantation in the mouse.
      Kruger RE, Frum T, Brumm AS, Hickey SL, Niakan KK, Aziz F, Shammami MA, Roberts JG, Ralston A. 2024 Jan 24; DOI:10.1101/2024.01.23.576717
      PMID: 38328075
    • Journal Article
      Multifaceted SOX2-chromatin interaction underpins pluripotency progression in early embryos.
      Li L, Lai F, Hu X, Liu B, Lu X, Lin Z, Liu L, Xiang Y, Frum T, Halbisen MA, Chen F, Fan Q, Ralston A, Xie W. Science, 2023 Dec 15; 382 (6676): eadi5516 DOI:10.1126/science.adi5516
      PMID: 38096290
    • Journal Article
      Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the developing human lung.
      Frum T, Hsu PP, Hein RFC, Conchola AS, Zhang CJ, Utter OR, Anand A, Zhang Y, Clark SG, Glass I, Sexton JZ, Spence JR. NPJ Regen Med, 2023 Sep 9; 8 (1): 48 DOI:10.1038/s41536-023-00325-z
      PMID: 37689780
    • Journal Article
      Type I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infection.
      Bragazzi Cunha J, Leix K, Sherman EJ, Mirabelli C, Frum T, Zhang CJ, Kennedy AA, Lauring AS, Tai AW, Sexton JZ, Spence JR, Wobus CE, Emmer BT. J Virol, 2023 Dec 21; 97 (12): e0127623 DOI:10.1128/jvi.01276-23
      PMID: 37975674