Yunhao Wang, PhD
Research Investigator
Computational Medicine and Bioinformatics
Department of Computational Medicine and Bioinformatics
100 Washtenaw Avenue, Palmer Commons 2035B
Ann Arbor, MI 48109
[email protected]

Available to mentor
Yunhao Wang, PhD
Research Investigator
  • Qualifications
  • Research Overview
  • Links
  • Recent Publications
    • Qualifications
    • Postdoctoral Scholar
      Ohio State University, Department of Biomedical Informatics, 2021
    • Postdoctoral Scholar
      University of Iowa, Department of Internal Medicine, 2018
    • PhD
      University of Chinese Academy of Sciences, Beijing, 2018
    • BS
      Inner Mongolia University, Hohhot, 2013
    Research Overview

    • Technology: third-generation single-molecule long-read sequencing techniques developed by Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT); single-cell genome and transcriptome sequencing techniques

    • Biology: mammalian germ cell and early embryo development; embryonic stem cell differentiation and pluripotency reprogramming; cancers and neurological disorders; transposable element activation

    • Develop both experimental approaches and bioinformatics tools to bridge a methodological gap between sequencing technology and biological applications

    • Explore the regulatory principles of gene expression and transposable element activation at multiple omics layers (i.e., genome, epigenome, transcriptome and epitranscriptome)

    • Parse biomedical data to establish the link between basic research and clinical applications (e.g., predication, diagnosis and therapy of diseases)

    Links
    • https://scholar.google.com/citations?user=Q8_AQV4AAAAJ&hl=en
    • https://github.com/yunhaowang
    • http://augroup.org/people.html
    • https://medicine.umich.edu/dept/dcmb/yunhao-wang-phd
    Recent Publications See All Publications
    • Journal Article
      Single-cell m6A mapping in vivo using picoMeRIP-seq.
      Li Y, Wang Y, Vera-Rodriguez M, Lindeman LC, Skuggen LE, Rasmussen EMK, Jermstad I, Khan S, Fosslie M, Skuland T, Indahl M, Khodeer S, Klemsdal EK, Jin K-X, Dalen KT, Fedorcsak P, Greggains GD, Lerdrup M, Klungland A, Au KF, Dahl JA. Nat Biotechnol, 2024 Apr; 42 (4): 591 - 596. DOI:10.1038/s41587-023-01831-7
      PMID: 37349523
    • Journal Article
      The RNA m6A landscape of mouse oocytes and preimplantation embryos.
      Wang Y, Li Y, Skuland T, Zhou C, Li A, Hashim A, Jermstad I, Khan S, Dalen KT, Greggains GD, Klungland A, Dahl JA, Au KF. Nat Struct Mol Biol, 2023 May; 30 (5): 703 - 709. DOI:10.1038/s41594-023-00969-x
      PMID: 37081317
    • Software / App
      MeRipBox: MeRIP-seq data analysis pipeline
      Wang Y. 2022 Feb 1;
    • Presentation
      Single-cell RNA m6A methylome in mouse oocytes and early embryos
      Wang Y. 2022 Jan 10;
    • Journal Article
      Nanopore sequencing technology, bioinformatics and applications.
      Wang Y, Zhao Y, Bollas A, Wang Y, Au KF. Nat Biotechnol, 2021 Nov; 39 (11): 1348 - 1365. DOI:10.1038/s41587-021-01108-x
      PMID: 34750572
    • Journal Article
      iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.
      Chen S, Wu J, Zhong S, Li Y, Zhang P, Ma J, Ren J, Tan Y, Wang Y, Au KF, Siebold C, Bond GL, Chen Z, Lu M, Jones EY, Lu X. Proc Natl Acad Sci U S A, 2019 Aug 27; 116 (35): 17470 - 17479. DOI:10.1073/pnas.1909393116
      PMID: 31395738
    • Journal Article
      MED25 connects enhancer-promoter looping and MYC2-dependent activation of jasmonate signalling.
      Wang H, Li S, Li Y, Xu Y, Wang Y, Zhang R, Sun W, Chen Q, Wang X-J, Li C, Zhao J. Nat Plants, 2019 Jun; 5 (6): 616 - 625. DOI:10.1038/s41477-019-0441-9
      PMID: 31182849
    • Journal Article
      Single-molecule long-read sequencing reveals the chromatin basis of gene expression.
      Wang Y, Wang A, Liu Z, Thurman AL, Powers LS, Zou M, Zhao Y, Hefel A, Li Y, Zabner J, Au KF. Genome Res, 2019 Aug; 29 (8): 1329 - 1342. DOI:10.1101/gr.251116.119
      PMID: 31201211