Molecular basis for potent B cell responses to antigen displayed on particles of viral size
Schematic of the library of liposomes engineered to display virus-like antigens (Ag) in a specific orientation and at a programmable density.
To understand how B cells signal in response to antigen display on viruses, researchers in the laboratory of Wei Cheng and their collaborators at UCSF engineered a set of virus-sized liposomes to display affinity mutants of the model antigen hen egg lysozyme (HEL), in the absence of nucleic acid cargo. Their studies of B cell responses to these synthetic particles led them to propose a novel signal transduction mechanism employed by B cells for recognition of virus-like antigens.
Professor
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Adina Turcu, MD, MS is an Associated Professor of Internal Medicine in the Division of Metabolism, Endocrinology & Diabetes, dedicated to providing comprehensive and compassionate care to her patients.
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Sixteen faculty and staff, and members of the Comprehensive Stroke Program, were honored Dec. 4 at the annual Faculty and Staff Awards ceremony at the Jack Roth Stadium Club in Michigan Stadium. The awards acknowledge and celebrate those who demonstrate exceptional accomplishment in the areas of teaching, research, clinical care, community service, technology, leadership, teamwork and administration
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