Research Assistant Professor
Biological Chemistry
[email protected]
Available to mentor
Markus Ruetz, PhD
Research Assistant Professor
Biochemical characterization of the human vitamin B12 trafficking proteins and enzymology of vitamin B12 dependent enzymes. Synthesis and characterization of non-natural vitamin B12 derivatives.
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Ruetz M, Mascarenhas R, Widner F, Kieninger C, Koutmos M, Kräutler B, Banerjee R. Biochemistry, 2024 Aug 6; 63 (15): 1955 - 1962.Journal ArticleA Noble Metal Substitution Leads to B12 Cofactor Mimicry by a Rhodibalamin.
DOI:10.1021/acs.biochem.4c00216 PMID: 39012171 -
Gouda H, Li Z, Ruetz M, Banerjee R. Inorg Chem, 2023 Aug 14; 62 (32): 12630 - 12633.Journal ArticleCoordination Chemistry Controls Coenzyme B12 Synthesis by Human Adenosine Triphosphate:Cob(I)alamin Adenosyltransferase.
DOI:10.1021/acs.inorgchem.3c02163 PMID: 37526260 -
Mascarenhas R, Guha A, Li Z, Ruetz M, An S, Seravalli J, Banerjee R. 2023 Jul 25;PreprintCobalt-sulfur coordination chemistry drives B 12 loading onto methionine synthase.
DOI:10.1101/2023.07.25.550549 PMID: 37546824 -
Mascarenhas R, Ruetz M, Gouda H, Heitman N, Yaw M, Banerjee R. Nat Commun, 2023 Jul 19; 14 (1): 4332Journal ArticleArchitecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B12 delivery and repair.
DOI:10.1038/s41467-023-40077-4 PMID: 37468522 -
Ruetz M. 2023 Mar 25;PresentationThe impact of patient mutations on coenzyme B12 loading and repair
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Mascarenhas R, Ruetz M, Gouda H, Heitman N, Yaw M, Banerjee R. 2023 Mar 23;PreprintArchitecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B 12 delivery and repair.
DOI:10.1101/2023.03.23.533963 PMID: 36993209 -
Gouda H, Mascarenhas R, Ruetz M, Yaw M, Banerjee R. Proc Natl Acad Sci U S A, 2023 Mar 14; 120 (11): e2220677120Journal ArticleBivalent molecular mimicry by ADP protects metal redox state and promotes coenzyme B12 repair.
DOI:10.1073/pnas.2220677120 PMID: 36888659 -
Ruetz M, Mascarenhas R, Gouda H, Heitman N, Banerjee R. Journal of Biological Chemistry, 2023 299 (3): s336Journal ArticleAbstract 2200: The impact of patient mutations on coenzyme B12 loading and repair
DOI:10.1016/j.jbc.2023.103647
Department News
Yan Zhang, PhD, Jeanne Stuckey, PhD, Markus Ruetz, PhD, Michael Cianfrocco, PhD, and Wei Cheng, PhD, have been promoted.
