Available to mentor
I have been a scientist for the past 25 years during which time I have assumed a number of different roles at various institutions and companies. My primary focus and goal has, and will continue to remain, on identifying ways in which I can benefit humankind, be it in the realm of cancer (targeted therapeutics, evidence-based information services for physician-driven treatment options) or renal cystogenesis (the study of signaling pathways that contribute to disease development and identifying potential therapeutic options). I strongly believe in collaborative science, and the bringing together of multiple different disciplines to investigate a problem from a variety of perspectives.
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Postdoctoral Research FellowNational Institutes of Health, Laboratory of Genetics and Physiology, 2003
My primary research interests lie in studying signal transduction pathways and how they contribute to the development and progression of disease in epithelial systems. Most recently this has been in the context of Polycystic Kidney Disease (PKD), which currently has only one FDA-approved therapy. My latest research has uncovered a potential novel role of defective nutrient sensing as a contributor to PKD.
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Shillingford JM. 2023 Nov 3;PresentationIs polycystin-1 a jack of all trades, but a master of none?
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Shillingford JM. 2023 Jun 24;PresentationDefining a role for transcription factor EB (TFEB) in Polycystic Kidney Disease (PKD).
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Shillingford JM. 2023 Jun 13;PresentationDefining a role for transcription factor EB (TFEB) in renal cystic disease
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Shillingford JM, Shayman JA. Am J Physiol Renal Physiol, 2023 Apr 1; 324 (4): F404 - F422.Journal ArticleFunctional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1.
DOI:10.1152/ajprenal.00237.2022 PMID: 36794754 -
Shillingford JM. 2023 Mar 28;Additional ScholarshipImage selected for the cover of AJP:Renal (April 2023).
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Shillingford JM. 2022 Nov 29;PresentationDefining a role for transcription factor EB (TFEB) in Polycystic Kidney Disease (PKD).
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Hinkovska-Galcheva V, Treadwell T, Shillingford JM, Lee A, Abe A, Tesmer JJG, Shayman JA. Journal of Lipid Research, 2021 Jun 1; 62: 1 - 23.Journal ArticleInhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis.
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Hinkovska-Galcheva V, Treadwell T, Shillingford JM, Lee A, Abe A, Tesmer JJG, Shayman JA. J Lipid Res, 2021 62: 100089Journal ArticleInhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis.
DOI:10.1016/j.jlr.2021.100089 PMID: 34087196