Leena Haataja
Associate Research Scientist
Internal Medicine
Metabolism, Endocrinology and Diabetes
1000 Wall Street #5418
Ann Arbor, Michigan 43105
[email protected]

Available to mentor
Leena Haataja
Associate Research Scientist
  • Qualifications
  • Center Memberships
  • Recent Publications
    • Qualifications
    • Postdoctoral Fellow
      the Keck School of Medicine of the University of Southern California, Division of Endocrinology and Diabetes, 2004
    • Postdoctoral fellow
      Children’s Hospital Los Angeles Research Institute, Division of Hematology/Oncology, 2001
    • PhD
      University of Kuopio, Kuopio, 1998
    • MS
      University of Kuopio, Kuopio, 1990
    • MS
      University of Kuopio, Kuopio, 1989
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    Recent Publications See All Publications
    • Preprint
      Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes
      Alam M, Arunagiri A, Haataja L, Torres M, Larkin D, Kappler J, Jin N, Arvan P. 2021 bioRxiv, DOI:10.1101/2021.06.01.446633
    • Journal Article
      Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis.
      Arunagiri A, Alam M, Haataja L, Draz H, Alasad B, Samy P, Sadique N, Tong Y, Cai Y, Shakeri H, Fantuzzi F, Ibrahim H, Jang I, Sidarala V, Soleimanpour SA, Satin LS, Otonkoski T, Cnop M, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Protein Sci, 2024 Apr; 33 (4): e4949 DOI:10.1002/pro.4949
      PMID: 38511500
    • Journal Article
      Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity.
      Zhang Y, Sui L, Du Q, Haataja L, Yin Y, Viola R, Xu S, Nielsson CU, Leibel RL, Barbetti F, Arvan P, Egli D. Mol Metab, 2024 Feb; 80: 101879 DOI:10.1016/j.molmet.2024.101879
      PMID: 38237895
    • Preprint
      Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity.
      Zhang Y, Sui L, Du Q, Haataja L, Yin Y, Viola R, Xu S, Nielsson CU, Leibel RL, Barbetti F, Arvan P, Egli D. 2023 Sep 15; DOI:10.1101/2023.09.01.555839
      PMID: 37745320
    • Journal Article
      Nutrient-dependent regulation of β-cell proinsulin content.
      Xu X, Arunagiri A, Alam M, Haataja L, Evans CR, Zhao I, Castro-Gutierrez R, Russ HA, Demangel C, Qi L, Tsai B, Liu M, Arvan P. J Biol Chem, 2023 Jul; 299 (7): 104836 DOI:10.1016/j.jbc.2023.104836
      PMID: 37209827
    • Journal Article
      Integration of ER protein quality control mechanisms defines β cell function and ER architecture.
      Shrestha N, Torres M, Zhang J, Lu Y, Haataja L, Reinert RB, Knupp J, Chen Y-J, Parlakgul G, Arruda AP, Tsai B, Arvan P, Qi L. J Clin Invest, 2023 Jan 3; 133 (1): DOI:10.1172/JCI163584
      PMID: 36346671
    • Journal Article
      Adaptation to chronic ER stress enforces pancreatic β-cell plasticity.
      Chen C-W, Guan B-J, Alzahrani MR, Gao Z, Gao L, Bracey S, Wu J, Mbow CA, Jobava R, Haataja L, Zalavadia AH, Schaffer AE, Lee H, LaFramboise T, Bederman I, Arvan P, Mathews CE, Gerling IC, Kaestner KH, Tirosh B, Engin F, Hatzoglou M. Nat Commun, 2022 Aug 8; 13 (1): 4621 DOI:10.1038/s41467-022-32425-7
      PMID: 35941159
    • Journal Article
      Proteasomal degradation of WT proinsulin in pancreatic beta cells.
      Xu X, Arunagiri A, Haataja L, Alam M, Ji S, Qi L, Tsai B, Liu M, Arvan P. J Biol Chem, 2022 Oct; 298 (10): 102406 DOI:10.1016/j.jbc.2022.102406
      PMID: 35988641