Ann Arbor
Michigan, 48109-5642
Available to mentor
Dr. Huang is an adult pulmonologist and physician-scientist at the University of Michigan, who holds joint appointments in the Department of Internal Medicine (Pulmonary/Critical Care Medicine) and the Department of Microbiology/Immunology. She is an expert in cystic fibrosis and internationally recognized for her research expertise on host-microbiome interactions in asthma and COPD. Dr. Huang has led seminal studies in this area including NIH-supported multicenter investigations. Her research has identified novel links between the airway microbiome, disease phenotype and clinical outcomes including treatment response.
Dr. Huang leads an inter-disciplinary translational research program incorporating clinical research, laboratory-based work and computational methods. Dr. Huang completed her training in internal medicine at Yale and pulmonary and critical care fellowship at the University of California San Francisco. She has served on numerous working groups and committees, including for the National Academy of Science, Engineering and Medicine. She is a Fellow of the American Thoracic Society and the American Academy of Allergy, Asthma and Immunology.
Honors/Awards
2001 Alpha Omega Alpha
2002, 2004 Yale/Johnson & Johnson Physician Scholar in International Health
2009 First prize clinical research, Sixth Annual Respiratory Disease Young Investigator Forum
2016 Young Physician-Scientist Award, American Society for Clinical Investigation
2017 Science and Innovation Center Rising Star in Research Award, American Thoracic Society
2019 Jo Rae Wright Award for Outstanding Science, American Thoracic Society
2020 Fellow of the American Thoracic Society (ATSF), American Thoracic Society
2023 Fellow of the American Academy of Allergy, Asthma and Immunology (FAAAAI),
2023 Distinguished Clinical and Translational Research Mentor Award, Michigan Institute for Clinical and Health Research (MICHR)
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Post-doctoral research fellowshipUniversity of California, San Francisco, San Francisco, 2010
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Pulmonary/Critical Care FellowshipUniversity of California, San Francisco, San Francisco, 2008
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Internal Medicine ResidencyYale New Haven Hospital, New Haven, 2004
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MDUniversity of Alabama, 1720 2nd Ave. S. FOT 1203, 2001
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BSStanford University, Stanford, 1997
Microbiome-host interactions in asthma and treatment response
Microbiome-host interactions in COPD pathogenesis and phenotype
Multi-‘omics, computational modeling of microbiome interactions in asthma and COPD.
Cystic Fibrosis in adults
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Liao Y, Cavalcante RG, Waller JB, Deng F, Scruggs AM, Huang YJ, Atasoy U, Chen Y, Huang SK. Clin Epigenetics, 2024 Oct 8; 16 (1): 139Journal ArticleDifferences in the DNA methylome of T cells in adults with asthma of varying severity.
DOI:10.1186/s13148-024-01750-7 PMID: 39380119 -
Yagi K, Ethridge AD, Falkowski NR, Huang YJ, Elesela S, Huffnagle GB, Lukacs NW, Fonseca W, Asai N. Am J Physiol Lung Cell Mol Physiol, 2024 Nov 1; 327 (5): L646 - L660.Journal ArticleMicrobiome modifications by steroids during viral exacerbation of asthma and in healthy mice.
DOI:10.1152/ajplung.00040.2024 PMID: 39159427 -
Burnim M, Putcha N, LaFon D, Woo H, Azar A, Groenke L, Stampfli M, Schaub A, Fawzy A, Balasubramanian A, Fedarko N, Cooper CB, Bowler RP, Comellas A, Krishnan JA, Han MK, Couper D, Peters SP, Drummond MB, O'Neal W, Paine R, Criner G, Martinez FJ, Curtis JL, Barr G, Huang YJ, Woodruff P, Dransfield M, Hansel NN. Am J Respir Crit Care Med, 2024 Oct 23;Journal ArticleSerum Immunoglobulin G Levels Are Associated with Risk for Exacerbations: An Analysis of SPIROMICS.
DOI:10.1164/rccm.202311-2184OC PMID: 39441116 -
Huang YJ. Am J Respir Crit Care Med, 2024 Aug 1; 210 (3): 252 - 253.Journal ArticleOf Mucus and Microbes: The Sticky Issue of Mucin-Microbiome Interactions in Chronic Obstructive Pulmonary Disease.
DOI:10.1164/rccm.202403-0506ED PMID: 38530107 -
Opron K, Begley LA, Erb-Downward JR, Li G, Alexis NE, Barjaktarevic I, Barr RG, Bleecker ER, Boucher R, Bowler RP, Christenson SA, Comellas AP, Criner G, Cooper CB, Couper D, Galban CJ, Han MK, Hastie A, Hatt C, Hoffman EA, Kaner RJ, Kesimer M, Krishnan JA, LaFon DC, Martinez FJ, Ortega VE, Peters SP, Paine R, Putcha N, Woodruff PG, Huffnagle GB, Kozik AJ, Curtis JL, Huang YJ, SPIROMICS Investigators . Am J Respir Crit Care Med, 2024 Jul 15; 210 (2): 186 - 200.Journal ArticleLoss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease.
DOI:10.1164/rccm.202303-0489OC PMID: 38261629 -
Yeung-Luk BH, Wally A, Swaby C, Jauregui S, Lee E, Zhang R, Chen D, Luk SH, Upadya N, Tieng E, Wilmsen K, Sherman E, Sudhakar D, Luk M, Shrivastav AK, Cao S, Ghosh B, Christenson SA, Huang YJ, Ortega VE, Biswal S, Tang W-Y, Sidhaye VK. Am J Respir Cell Mol Biol, 2024 Mar; 70 (3): 165 - 177.Journal ArticleEpigenetic Reprogramming Drives Epithelial Disruption in Chronic Obstructive Pulmonary Disease.
DOI:10.1165/rcmb.2023-0147OC PMID: 37976469 -
Yuan H, Liu Z, Dong J, Bacharier LB, Jackson D, Mauger D, Boushey H, Castro M, Durack J, Huang YJ, Lemanske RF, Storch GA, Weinstock GM, Wylie K, Covar R, Fitzpatrick AM, Phipatanakul W, Robison RG, Beigelman A, Zhou Y. Chest, 2023 Aug; 164 (2): 302 - 313.Journal ArticleThe Fungal Microbiome of the Upper Airway Is Associated With Future Loss of Asthma Control and Exacerbation Among Children With Asthma.
DOI:10.1016/j.chest.2023.03.034 PMID: 37003356 -
Ghedin E, Huang YJ. Am J Respir Crit Care Med, 2023 Jul 15; 208 (2): 119 - 121.Journal ArticleOral Microbiota and Pediatric Asthma Phenotype: A New Window for Biomarkers?
DOI:10.1164/rccm.202305-0856ED PMID: 37276885
