Viviane Hambrecht-Wiedbusch, PhD
Assistant Research Scientist
Anesthesiology
Anesthesiology
7433 Medical Science Building I, 1150 West Medical Center Drive
Ann Arbor, Michigan 48109-0615
[email protected]

Available to mentor
Viviane Hambrecht-Wiedbusch, PhD
Assistant Research Scientist
  • Qualifications
  • Research Overview
  • Links
  • Recent Publications
    • Qualifications
    • Postdoctoral Fellow
      University of Michigan Medical School, Anesthesiology, 2009
    • PhD
      Department of Animal Physiology, University of Tübingen, Tübingen, 2004
    Research Overview

    Regulation of Arousal States and Neural Correlates of Consciousness.- The research focuses on neural mechanisms underlying the generation of arousal states of sleep and wakefulness, as well as the neural regulation of the loss and resumption of consciousness with respect to general anesthesia.

    - Sleep and Pain Interactions.- The research focuses on the brain circuitry by which sleep disruption increases pain and paves the way for chronic pain.

    Links
    • https://vanini.med.umich.edu/members/
    • https://scholar.google.com/citations?user=pOesgYsAAAAJ&hl=en&authuser=1
    Recent Publications See All Publications
    • Preprint
      Regulation of REM Sleep Onset and Homeostasis by Preoptic Glutamatergic Neurons
      Mondino A, Jadidian A, Toth B, Hambrecht-Wiedbusch VS, Floran-Garduno L, Li D, York AK, Torterolo P, Pal D, Burgess C, Mashour GA, Vanini G. bioRxiv, DOI:10.1101/2024.10.03.616573
    • Journal Article
      Glutamatergic Neurons in the Preoptic Hypothalamus Promote Wakefulness, Destabilize NREM Sleep, Suppress REM Sleep, and Regulate Cortical Dynamics.
      Mondino A, Hambrecht-Wiedbusch VS, Li D, York AK, Pal D, González J, Torterolo P, Mashour GA, Vanini G. J Neurosci, 2021 Apr 14; 41 (15): 3462 - 3478. DOI:10.1523/JNEUROSCI.2718-20.2021
      PMID: 33664133
    • Proceeding / Abstract / Poster
      0140 Chemogenetic Activation of GABAergic and Glutamatergic Neurons in the Median Preoptic Nucleus Does Not Alter Isoflurane Anesthesia
      Bassana M, Mast M, Cerda I, Hambrecht-Wiedbusch VS, Mashour GA, Vanini G. Sleep, 2019 Apr 13; 42 (Supplement_1): a57 - a58. DOI:10.1093/sleep/zsz067.139
    • Journal Article
      Propofol, Sevoflurane, and Ketamine Induce a Reversible Increase in Delta-Gamma and Theta-Gamma Phase-Amplitude Coupling in Frontal Cortex of Rat.
      Pal D, Silverstein BH, Sharba L, Li D, Hambrecht-Wiedbusch VS, Hudetz AG, Mashour GA. Front Syst Neurosci, 2017 11: 41 DOI:10.3389/fnsys.2017.00041
      PMID: 28659769
    • Journal Article
      Accelerated Recovery of Consciousness after General Anesthesia Is Associated with Increased Functional Brain Connectivity in the High-Gamma Bandwidth.
      Li D, Hambrecht-Wiedbusch VS, Mashour GA. Front Syst Neurosci, 2017 11: 16 DOI:10.3389/fnsys.2017.00016
      PMID: 28392760
    • Figure
      Schematic showing a modified Raturn in which the animal can freely behave while EEG/EMG data are recorded and microdialysis sampling is performed during various levels of arousal (Figure 1B, Anesthesiology, 126(3): 482-494, 03/2017. PM28099246).
      Hambrecht-Wiedbusch V. 2017 Mar;
    • Additional Scholarship
      An anesthetic paradox: ketamine deepens anesthesia but accelerates recovery
      Hambrecht-Wiedbusch VS, Li D, Mashour GA. 2017
    • Journal Article
      Preemptive Caffeine Administration Blocks the Increase in Postoperative Pain Caused by Previous Sleep Loss in the Rat: A Potential Role for Preoptic Adenosine A2A Receptors in Sleep-Pain Interactions.
      Hambrecht-Wiedbusch VS, Gabel M, Liu LJ, Imperial JP, Colmenero AV, Vanini G. Sleep, 2017 Sep 1; 40 (9): DOI:10.1093/sleep/zsx116
      PMID: 28934532