Associate Research Scientist
Internal Medicine
[email protected]
Available to mentor
Thomas M Lanigan
Associate Research Scientist
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Kaur G, Wu B, Murali S, Lanigan T, Coleman RM. FASEB J, 2024 Feb 29; 38 (4): e23484Journal ArticleA synthetic, closed-looped gene circuit for the autonomous regulation of RUNX2 activity during chondrogenesis.
DOI:10.1096/fj.202300348RR PMID: 38407380 -
Pan G, Roy B, Harding P, Lanigan T, Hilgarth R, Thandavarayan RA, Palaniyandi SS. Gene Ther, 2023 Feb; 30 (1-2): 115 - 121.Journal ArticleEffects of intracardiac delivery of aldehyde dehydrogenase 2 gene in myocardial salvage.
DOI:10.1038/s41434-022-00345-2 PMID: 35606494 -
Aring L, Choi E-K, Kopera H, Lanigan T, Iwase S, Klionsky DJ, Seo YA. J Neurochem, 2022 Feb; 160 (3): 356 - 375.Journal ArticleA neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation.
DOI:10.1111/jnc.15548 PMID: 34837396 -
Schardt JS, Pornnoppadol G, Desai AA, Park KS, Zupancic JM, Makowski EK, Smith MD, Chen H, Garcia de Mattos Barbosa M, Cascalho M, Lanigan TM, Moon JJ, Tessier PM. Sci Rep, 2021 Oct 20; 11 (1): 20738Journal ArticleDiscovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening.
DOI:10.1038/s41598-021-99401-x PMID: 34671080 -
Zupancic JM, Desai AA, Schardt JS, Pornnoppadol G, Makowski EK, Smith MD, Kennedy AA, Garcia de Mattos Barbosa M, Cascalho M, Lanigan TM, Tai AW, Tessier PM. Cell Chem Biol, 2021 Sep 16; 28 (9): 1379 - 1388.e7.Journal ArticleDirected evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis.
DOI:10.1016/j.chembiol.2021.05.019 PMID: 34171229 -
Zupancic JM, Schardt JS, Desai AA, Makowski EK, Smith MD, Pornnoppadol G, Garcia de Mattos Barbosa M, Cascalho M, Lanigan TM, Tessier PM. Adv Ther (Weinh), 2021 Aug; 4 (8): 2100099Journal ArticleEngineered Multivalent Nanobodies Potently and Broadly Neutralize SARS-CoV-2 Variants.
DOI:10.1002/adtp.202100099 PMID: 34514086 -
de Mattos Barbosa MG, Liu H, Huynh D, Shelley G, Keller ET, Emmer BT, Sherman E, Ginsburg D, Kennedy AA, Tai AW, Wobus C, Mirabeli C, Lanigan TM, Samaniego M, Meng W, Rosenfeld AM, Prak ETL, Platt JL, Cascalho M. JCI Insight, 2021 May 10; 6 (9):Journal ArticleIgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity.
DOI:10.1172/jci.insight.147386 PMID: 33769311 -
Wu B, Kaur G, Murali S, Lanigan T, Coleman RM. bioRxiv, 2021 Apr 20; 2021.04.20.440669:Journal ArticleAutonomous Regulation of RUNX2 Activity during Adult Human Mesenchymal Stem Cell Chondrogenesis using a Synthetic, Closed-Looped Gene Circuit.
