Doug Engel, PhD
Professor Emeritus of Cell and Developmental Biology
[email protected]

Available to mentor
Doug Engel, PhD
Professor Emeritus/a
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • Qualifications
    • postdoctoral fellow
      Caltech, Biology
    • PhD
      University of Oregon, Eugene, 1975
    • BA
      Revelle College, U.C. San Diego, La Jolla, 1970
    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    Research Overview

    Transcriptional regulation of mammalian development; chromatin and epigenetics; hemoglobinopathies

    Recent Publications See All Publications
    • Journal Article
      Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency.
      Hirano I, Abe K, Engel JD, Yamamoto M, Shimizu R. Exp Hematol Oncol, 2024 Feb 26; 13 (1): 23 DOI:10.1186/s40164-024-00491-w
      PMID: 38409047
    • Journal Article
      The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice.
      Ishihara D, Hasegawa A, Hirano I, Engel JD, Yamamoto M, Shimizu R. Exp Hematol Oncol, 2024 Feb 26; 13 (1): 24 DOI:10.1186/s40164-024-00492-9
      PMID: 38409186
    • Journal Article
      TR4 and BCL11A Repress γ-globin Transcription via Independent Mechanisms.
      Wang Y, Myers G, Yu L, Deng K, Balbin-Cuesta G, Singh SA, Guan Y, Khoriaty R, Engel JD. Blood, 2024 Oct 11; DOI:10.1182/blood.2024024599
      PMID: 39393056
    • Journal Article
      A Genome Scale CRISPR Screen Identifies Novel Genes That Regulate Erythropoietin Production
      Lin Z, Balbin-Cuesta G, Myers G, Yu L, Drysdale C, Tang V, Ozel AB, Friedman A, McGee B, Ito M, Saba R, Kerpet C, King R, Patrick G, Engel J, Khoriaty R. Blood, 2023 Nov 2; 142 (Supplement 1): 3820 DOI:10.1182/blood-2023-182427
    • Journal Article
      Direct and Indirect Functions of TR4 in the Control of Fetal Hemoglobin Silencing
      Wang Y, Yu L, Myers G, Singh SA, Engel J. Blood, 2023 Nov 2; 142 (Supplement 1): 555 DOI:10.1182/blood-2023-181113
    • Journal Article
      Disruption of the Malate-Aspartate Shuttle Leads to Anemia
      Pourmandi N, Myers G, Temprine K, Sankar A, Nelson N, Shah Y, Lyssiotis C, Engel J, Khoriaty R. Blood, 2023 Nov 2; 142 (Supplement 1): 3823 DOI:10.1182/blood-2023-188220
    • Journal Article
      Identification of CNOT4 As a Positive Regulator of Erythroid Cell Growth Using a Genome Wide CRISPR Knock-out Screen
      Drysdale C, Myers G, Yu L, Friedman A, Kerpet C, Balbin-Cuesta G, Lin Z, Ozel AB, Engel J, Khoriaty R. Blood, 2023 Nov 2; 142 (Supplement 1): 2447 DOI:10.1182/blood-2023-182187
    • Journal Article
      Whole-Genome CRISPR-Cas9 Screen Identifies ZBTB7A As a Potential Therapeutic Target for Cda-II
      Yu L, Myers G, McGee B, Liu X, Patrick G, King R, Friedman A, Balbin-Cuesta G, Lin Z, Drysdale C, Kerpet C, Sharon S, Engel J, Khoriaty R. Blood, 2023 Nov 2; 142 (Supplement 1): 12 DOI:10.1182/blood-2023-182246