Available to mentor
Dr. Alexandra S. Piotrowski-Daspit, Ph.D. (she/her) is an Assistant Professor of Biomedical Engineering and Internal Medicine – Pulmonary and Critical Care Medicine at the University of Michigan. She trained as a chemical/biological engineer and has expertise in developing polymeric biomaterials for therapeutic delivery, primarily in the context of gene therapies. Dr. Piotrowski-Daspit is the Principal Investigator of a diverse and interdisciplinary research group. Using high-throughput in vivo studies and computational pharmacokinetic models, her translational research program focuses on understanding how delivery vehicles behave in the body as well as developing strategies to influence biodistribution and optimize gene delivery to target tissues and cell types. To complement her research, Dr. Piotrowski-Daspit is committed to teaching and mentoring the next generation of scientists and leading diversity, equity, and inclusion initiatives.
-
Center MemberCenter for Cell Plasticity and Organ Design
-
Piotrowski-Daspit AS, Bracaglia LG, Eaton DA, Richfield O, Binns TC, Albert C, Gould J, Mortlock RD, Egan ME, Pober JS, Saltzman WM. Nat Commun, 2024 May 18; 15 (1): 4247Journal ArticleEnhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys.
DOI:10.1038/s41467-024-48442-7 PMID: 38762483 -
Garrison A, Suberi A, Browne J, Eaton D, Akhtar L, Kizilirmak TK, Bruscia E, Piotrowski-Daspit A, Saltzman W, Egan M. Journal of Cystic Fibrosis, 2023 Oct; 22: s140Journal Article276 Delivery of CFTR mRNA using polymeric nanoparticles in a cystic fibrosis mouse model
DOI:10.1016/s1569-1993(23)01204-3 -
Richfield O, Piotrowski-Daspit AS, Shin K, Saltzman WM. J Control Release, 2023 Aug; 360: 772 - 783.Journal ArticleRational nanoparticle design: Optimization using insights from experiments and mathematical models.
DOI:10.1016/j.jconrel.2023.07.018 PMID: 37442201 -
Ullrich SJ, Yung NK, Bauer-Pisani TJ, Maassel NL, Guerra ME, Freedman-Weiss M, Ahle SL, Ricciardi AS, Sauler M, Saltzman WM, Piotrowski-Daspit AS, Stitelman DH. Mol Ther Nucleic Acids, 2023 Jun 13; 32: 594 - 602.Journal ArticleIn utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia.
DOI:10.1016/j.omtn.2023.04.018 PMID: 37200861 -
Piotrowski-Daspit AS, Suberi A, Bracaglia LG, Akhtar L, Ene M, Suh HW, Glazer PM, Saltzman WM. MOLECULAR THERAPY, 2023 31 (4): 475 - 475.Proceeding / Abstract / PosterGene Editing in the Lung Using Polymeric Vehicles
-
Suberi A, Grun MK, Mao T, Israelow B, Reschke M, Grundler J, Akhtar L, Lee T, Shin K, Piotrowski-Daspit AS, Homer RJ, Iwasaki A, Suh H-W, Saltzman WM. Sci Transl Med, 2023 Aug 16; 15 (709): eabq0603Journal ArticlePolymer nanoparticles deliver mRNA to the lung for mucosal vaccination.
DOI:10.1126/scitranslmed.abq0603 PMID: 37585505 -
Reschke M, Piotrowski-Daspit AS, Pober JS, Saltzman WM. Mol Pharm, 2022 Dec 5; 19 (12): 4466 - 4486.Journal ArticleNucleic Acid Delivery to the Vascular Endothelium.
DOI:10.1021/acs.molpharmaceut.2c00653 PMID: 36251765 -
Piotrowski-Daspit AS, Barone C, Lin C-Y, Deng Y, Wu D, Binns TC, Xu E, Ricciardi AS, Putman R, Garrison A, Nguyen R, Gupta A, Fan R, Glazer PM, Saltzman WM, Egan ME. Sci Adv, 2022 Oct 7; 8 (40): eabo0522Journal ArticleIn vivo correction of cystic fibrosis mediated by PNA nanoparticles.
DOI:10.1126/sciadv.abo0522 PMID: 36197984