Alexandra Piotrowski-Daspit
Assistant Professor of Biomedical Engineering
Assistant Professor of Internal Medicine
[email protected]

Available to mentor

Alexandra Piotrowski-Daspit
Assistant Professor
  • About
  • Center Memberships
  • Recent Publications
  • About

    Dr. Alexandra S. Piotrowski-Daspit, Ph.D. (she/her) is an Assistant Professor of Biomedical Engineering and Internal Medicine – Pulmonary and Critical Care Medicine at the University of Michigan. She trained as a chemical/biological engineer and has expertise in developing polymeric biomaterials for therapeutic delivery, primarily in the context of gene therapies. Dr. Piotrowski-Daspit is the Principal Investigator of a diverse and interdisciplinary research group. Using high-throughput in vivo studies and computational pharmacokinetic models, her translational research program focuses on understanding how delivery vehicles behave in the body as well as developing strategies to influence biodistribution and optimize gene delivery to target tissues and cell types. To complement her research, Dr. Piotrowski-Daspit is committed to teaching and mentoring the next generation of scientists and leading diversity, equity, and inclusion initiatives.

    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design
    Recent Publications See All Publications
    • Journal Article
      Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys.
      Piotrowski-Daspit AS, Bracaglia LG, Eaton DA, Richfield O, Binns TC, Albert C, Gould J, Mortlock RD, Egan ME, Pober JS, Saltzman WM. Nat Commun, 2024 May 18; 15 (1): 4247 DOI:10.1038/s41467-024-48442-7
      PMID: 38762483
    • Journal Article
      276 Delivery of CFTR mRNA using polymeric nanoparticles in a cystic fibrosis mouse model
      Garrison A, Suberi A, Browne J, Eaton D, Akhtar L, Kizilirmak TK, Bruscia E, Piotrowski-Daspit A, Saltzman W, Egan M. Journal of Cystic Fibrosis, 2023 Oct; 22: s140 DOI:10.1016/s1569-1993(23)01204-3
    • Journal Article
      Rational nanoparticle design: Optimization using insights from experiments and mathematical models.
      Richfield O, Piotrowski-Daspit AS, Shin K, Saltzman WM. J Control Release, 2023 Aug; 360: 772 - 783. DOI:10.1016/j.jconrel.2023.07.018
      PMID: 37442201
    • Journal Article
      In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia.
      Ullrich SJ, Yung NK, Bauer-Pisani TJ, Maassel NL, Guerra ME, Freedman-Weiss M, Ahle SL, Ricciardi AS, Sauler M, Saltzman WM, Piotrowski-Daspit AS, Stitelman DH. Mol Ther Nucleic Acids, 2023 Jun 13; 32: 594 - 602. DOI:10.1016/j.omtn.2023.04.018
      PMID: 37200861
    • Proceeding / Abstract / Poster
      Gene Editing in the Lung Using Polymeric Vehicles
      Piotrowski-Daspit AS, Suberi A, Bracaglia LG, Akhtar L, Ene M, Suh HW, Glazer PM, Saltzman WM. MOLECULAR THERAPY, 2023 31 (4): 475 - 475.
    • Journal Article
      Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination.
      Suberi A, Grun MK, Mao T, Israelow B, Reschke M, Grundler J, Akhtar L, Lee T, Shin K, Piotrowski-Daspit AS, Homer RJ, Iwasaki A, Suh H-W, Saltzman WM. Sci Transl Med, 2023 Aug 16; 15 (709): eabq0603 DOI:10.1126/scitranslmed.abq0603
      PMID: 37585505
    • Journal Article
      Nucleic Acid Delivery to the Vascular Endothelium.
      Reschke M, Piotrowski-Daspit AS, Pober JS, Saltzman WM. Mol Pharm, 2022 Dec 5; 19 (12): 4466 - 4486. DOI:10.1021/acs.molpharmaceut.2c00653
      PMID: 36251765
    • Journal Article
      In vivo correction of cystic fibrosis mediated by PNA nanoparticles.
      Piotrowski-Daspit AS, Barone C, Lin C-Y, Deng Y, Wu D, Binns TC, Xu E, Ricciardi AS, Putman R, Garrison A, Nguyen R, Gupta A, Fan R, Glazer PM, Saltzman WM, Egan ME. Sci Adv, 2022 Oct 7; 8 (40): eabo0522 DOI:10.1126/sciadv.abo0522
      PMID: 36197984