Research Assistant Professor
Computational Medicine and Bioinformatics
[email protected]
Available to mentor
Yue Zhao, PhD
Research Assistant Professor
My research focuses on developing and applying statistical methods for high-dimensional data integration in biomedical research. I have collaborated with basic science researchers and physicians to design optimal multi-omics data collection and perform advanced analyses, such as genomics, transcriptomics, proteomics, metabolomics, CRISPR-based genetic screening, and third-generation sequencing. My research goals include investigating the effects of environmental exposures on genome, epigenome, transcriptome, and epi-transcriptome in neurodegenerative diseases like ALS, as well as conducting multi-omics analysis to establish connections between exposures, omics, and disease risk.
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Liu J, Zhao Y, He D, Jones KM, Tang S, Allison DB, Zhang Y, Chen J, Zhang Q, Wang X, Li C, Wang C, Li L, Liu X. Cell Rep Med, 2023 Apr 18; 4 (4): 101015Journal ArticleA kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer.
DOI:10.1016/j.xcrm.2023.101015 PMID: 37075701 -
Zhao Y, Yu L, Wu X, Li H, Coombes KR, Au KF, Cheng L, Li L. Bioinformatics, 2022 Nov 30; 38 (23): 5245 - 5252.Journal ArticleCEDA: integrating gene expression data with CRISPR-pooled screen data identifies essential genes with higher expression.
DOI:10.1093/bioinformatics/btac668 PMID: 36250792 -
Li C, Liu J, He D, Mao F, Rao X, Zhao Y, Lanman NA, Kazemian M, Farah E, Liu J, Ngule CM, Zhang Z, Zhang Y, Kong Y, Li L, Wang C, Liu X. Oncogene, 2022 Sep; 41 (40): 4498 - 4511.Journal ArticleGSTM2 is a key molecular determinant of resistance to SG-ARIs.
DOI:10.1038/s41388-022-02444-1 PMID: 36038661 -
Cheng C, Geng F, Li Z, Zhong Y, Wang H, Cheng X, Zhao Y, Mo X, Horbinski C, Duan W, Chakravarti A, Cheng X, Guo D. Nat Metab, 2022 May; 4 (5): 575 - 588.Journal ArticleAmmonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth.
DOI:10.1038/s42255-022-00568-y PMID: 35534729 -
Wang Y, Zhao Y, Bollas A, Wang Y, Au KF. Nat Biotechnol, 2021 Nov; 39 (11): 1348 - 1365.Journal ArticleNanopore sequencing technology, bioinformatics and applications.
DOI:10.1038/s41587-021-01108-x PMID: 34750572 -
Wang Y, Wang A, Liu Z, Thurman AL, Powers LS, Zou M, Zhao Y, Hefel A, Li Y, Zabner J, Au KF. Genome Res, 2019 Aug; 29 (8): 1329 - 1342.Journal ArticleSingle-molecule long-read sequencing reveals the chromatin basis of gene expression.
DOI:10.1101/gr.251116.119 PMID: 31201211
