Available to mentor
Dr. Alumkal graduated summa cum laude from the University of Texas with a B.A. in Biology. Then, he received his medical degree from Baylor College of Medicine. He completed an internship, residency, and chief residency at UT Southwestern Medical Center. After completing a clinical fellowship in medical oncology at Johns Hopkins University, Dr. Alumkal completed a post-doctoral fellowship focused on cancer epigenetics in the Jim Herman Laboratory at Johns Hopkins. Dr. Alumkal joined the Knight Cancer Institute Prostate Cancer Research Program at Oregon Health and Science University (OHSU) in 2007 and became the co-Leader of the Program in 2013. In 2014, Dr. Alumkal was honored with the Richard T. Jones New Investigator Award for exceptional promise early in a career in biomedical research in Oregon. He was also named the inaugural holder of the Wayne D. Kuni and Joan E. Kuni Endowed Chair for Prostate Cancer Research at OHSU in 2017.
In 2019, Dr. Alumkal re-located to the University of Michigan to lead the Genitourinary Medical Oncology Section in the Division of Hematology-
Oncology and the Rogel Cancer Center, where he is a Professor of Internal Medicine. He was named a Rogel Cancer Center Rogel Scholar in 2019 and was elected to the American Society for Clinical Investigation that same year. Since 2020, he has been a Co-Leader of the Translational and Clinical Research Program in the Rogel Cancer Center. In 2021, Dr. Alumkal was named the inaugural Wicha Family Professor of Oncology at the University of Michigan.
The Alumkal Laboratory’s main emphasis is to understand how tumors change and adapt in response to treatment. The most important goals of Dr. Alumkal’s studies are to identify therapies that effectively target and interdict lethal prostate cancer progression in the laboratory and to conduct innovative clinical trials designed to validate the molecular and clinical effectiveness of novel therapeutic agents.
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Center MemberMM-PKUHSC Joint Institute
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Center MemberPrecision Health Initiative
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberRogel Cancer Center
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Feng E, Vo-Phamhi JMA, Foye A, Vinson J, Hong JC, Freedland SJ, Alumkal J, Beltran H, Morrissey C, Nelson P, Chinnaiyan A, Sawyers C, Aggarwal R, Small E, Quigley D, Sjostrom M, Zhao SG, Chen WS. International Journal of Radiation Oncology • Biology • Physics, 2024 Oct; 120 (2): e519Journal ArticleRacial Variation in the Advanced Prostate Cancer Genome
DOI:10.1016/j.ijrobp.2024.07.1152 -
Shrestha R, Chesner LN, Zhang M, Zhou S, Foye A, Lundberg A, Weinstein AS, Sjöström M, Zhu X, Moreno-Rodriguez T, Li H, SU2C/PCF West Coast Prostate Cancer Dream Team , Alumkal JJ, Aggarwal R, Small EJ, Lupien M, Quigley DA, Feng FY. Cancer Res, 2024 Sep 16; 84 (18): 3086 - 3100.Journal ArticleAn Atlas of Accessible Chromatin in Advanced Prostate Cancer Reveals the Epigenetic Evolution during Tumor Progression.
DOI:10.1158/0008-5472.CAN-24-0890 PMID: 38990734 -
2024 Sep 5;PresentationMulti-Omic Profiling Clarifies Mechanisms of Therapy-Induced Neuroendocrine Prostate Cancer Lineage Plasticity
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Vaishampayan UN, Kilari D, Dorff TB, Taylor J, Brown JT, Sokolova AO, Reichert Z, Palmbos P, Tsung I, Caram M, Yentz S, Alumkal J, Nazha B. Annals of Oncology, 2024 Sep; 35: s965Journal Article1600P Phase II trial of pembrolizumab and lenvatinib in advanced neuroendocrine prostate cancer (NEPC)
DOI:10.1016/j.annonc.2024.08.1681 -
Zhao SG, Bootsma M, Zhou S, Shrestha R, Moreno-Rodriguez T, Lundberg A, Pan C, Arlidge C, Hawley JR, Foye A, Weinstein AS, Sjöström M, Zhang M, Li H, Chesner LN, Rydzewski NR, Helzer KT, Shi Y, West Coast Dream Team Consortium , Lynch M, Dehm SM, Lang JM, Alumkal JJ, He HH, Wyatt AW, Aggarwal R, Zwart W, Small EJ, Quigley DA, Lupien M, Feng FY. Nat Genet, 2024 Aug; 56 (8): 1689 - 1700.Journal ArticleIntegrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer.
DOI:10.1038/s41588-024-01826-3 PMID: 39020220 -
Zhang M, Sjöström M, Cui X, Foye A, Farh K, Shrestha R, Lundberg A, Dang HX, Li H, Febbo PG, Aggarwal R, Alumkal JJ, Small EJ, SU2C/PCF West Coast Prostate Cancer Dream Team , Maher CA, Feng FY, Quigley DA. Nat Cell Biol, 2024 Jul; 26 (7): 1176 - 1186.Journal ArticleIntegrative analysis of ultra-deep RNA-seq reveals alternative promoter usage as a mechanism of activating oncogenic programmes during prostate cancer progression.
DOI:10.1038/s41556-024-01438-3 PMID: 38871824 -
Caram MEV, Kumbier K, Tsao PA, Burns J, Sparks JB, Stensland KD, Reichert ZR, Alumkal JJ, Hollenbeck BK, Shahinian V, Tsodikov A, Skolarus TA. Cancer Med, 2024 Jun; 13 (12): e7334Journal ArticleSurvival by first-line therapy and prognostic group among men with metastatic castration-resistant prostate cancer.
DOI:10.1002/cam4.7334 PMID: 39143030 -
Hu Y-M, Zhao F, Graff JN, Chen C, Zhao X, Thomas GV, Wu H, Kardosh A, Mills GB, Alumkal JJ, Moran AE, Xia Z. bioRxiv, 2024 May 14;Journal ArticleAndrogen receptor activity inversely correlates with immune cell infiltration and immunotherapy response across multiple cancer lineages.
DOI:10.1101/2024.05.08.593181 PMID: 38798471