Weihua Zhou, PhD
Research Assistant Professor
Radiation Oncology
Radiation Oncology
1301 Catherine Street
Ann Arbor, MI 48109
[email protected]

Available to mentor
Weihua Zhou, PhD
Research Assistant Professor
  • About
  • Qualifications
  • Research Overview
  • Recent Publications
    • About

    Dr. Zhou has been doing basic and translational cancer research for the past 15 years. Her research focuses on mechanistic study of interactions between guanine nucleotide–binding protein (G proteins) signaling pathways and DNA repair in in vitro and orthotopic models.

    Qualifications
    • Postdoctoral Research Fellow
      University of Michigan, Radiation Oncology, 2018
    Research Overview

    My primary research interest is focusing on signaling pathways, especially GTP signaling pathways. I am interested in investigating the correlation between GTP signaling pathway and DNA repair, digging out the mechanism how GTP signaling pathway regulates DNA repair, and exploring the function of GTP signaling pathway-regulated DNA repair in physiological processes (lymphocyte or blood cell development) and health diseases. Together, I will test whether GTP can serve as a metabolic biomarker for radiation resistance in cancers but a radioprotector in normal tissues and a crucial factor in physiological processes (lymphocyte or blood cell development) to provide preclinical data to design new clinical trials, explore new disease prevention and treatments.

    Recent Publications See All Publications
    • Presentation
      GTP signaling pathway promotes nhej repair by inducing nuclear actin polymerization
      Zhou W. 2024 Sep 12;
    • Journal Article
      Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma
      Peterson ER, Sajjakulnukit P, Scott AJ, Heaslip C, Andren A, Wilder-Romans K, Zhou W, Palavalasa S, Korimerla N, Lin A, O'Brien A, Kothari A, Zhao Z, Zhang L, Morgan MA, Venneti S, Koschmann C, Jabado N, Lyssiotis CA, Castro MG, Wahl DR. 2024 Apr 9;
    • Journal Article
      GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress
      Zhou W, Zhao W, Lin A, Yang JZ, Xu J, Wilder-Romans K, Yang A, Li J, Solanki S, Speth JM, Walker N, Scott AJ, Wang L, Wen B, Andren A, Zhang L, Kothari AU, Yao Y, Peterson ER, Korimerla N, Wener CK, Ullrich A, Liang J, Jacobson J, Palavalasa S, O'Brien AM, Elaimy AL, Ferris SP, Zhao SG, Sarkarian JN, Győrffy B, Zhang S, Al-Holou WN, Umemura Y, Morgan MA, Lawrence TS, Lyssiotis CA, Peters-Golden M, Shah YM, Wahl DR. Cancer Discovery, 2024 Jan 12;
    • Journal Article
      GTP signaling links metabolism, DNA repair, and responses to genotoxic stress
      Zhou W, Zhao Z, Lin A, Yang J, Xu J, Wilder-Romans K, Yang A, Li J, Solanki S, Speth J, Walker N, Scott A, Kothari A, Yao Y, Peterson E, Korimerla N, Werner C, Liang J, Jacobson J, Palavalasa S, Obrien A, Elaimy A, Ferris S, Zhao S, Sarkaria J, Győrffy B, Zhang S, Al-Holou W, Umemura Y, Morgan M, Lawrence T, Lyssiotis C, Peters-Golden M, Shah Y, Wahl D. BioRxiv, 2023 Dec 6; DOI:10.1101/2023.04.12.536297
    • Presentation
      GTP signaling links metabolism, DNA repair, and responses to genotoxic stress
      Zhou W. 2023 Nov 15;
    • Presentation
      GTP signaling links cancer metabolism, DNA repair and treatment resistance
      Zhou W. 2023 Aug 30;
    • Presentation
      GTP-dependent signaling links metabolism, non-homologous end joining and treatment responses in cancer and normal tissues
      Zhou W. 2023 Apr 14;
    • Presentation
      Molecular links between GTP and DNA repair. "Bagel talk"
      Zhou W. 2022 Mar 2;