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Steven L. Kunkel, Ph.D., is executive vice dean for research in the Medical School and chief scientific officer for Michigan Medicine, effective Sept. 1, 2019. He serves the faculty as the Endowed Professor of Pathology Research and the Peter A. Ward Distinguished University Professor.
Kunkel has a long and robust history with the University of Michigan. He has served in various leadership and administrative positions, including interim associate vice president for research; associate dean for interdisciplinary studies, Horace H. Rackham Graduate School; interim dean of the Rackham Graduate School; interim vice provost for academic affairs; and co-director of Departmental Research, Department of Pathology.
His research interests have centered on assessing molecular mechanisms of lung inflammation by studying cytokine and chemokine biology. His studies are internationally recognized and have provided a more clear understanding of how these proteins participate in the initiation, maintenance, and resolution of acute and chronic lung. His research group has provided evidence for specific cytokine phenotypes that dictate the progression of particular chronic diseases.
His impact in the field of immunology and inflammation can be effectively demonstrated in a variety of ways: He has co-authored more than 600 peer-reviewed manuscripts, contributed more than 60 chapters to different books in his field, served as the editor for four books, presented more than 150 lectures as a visiting professor/lecturer in the past 10 years, maintained continuous funding of multiple National Institute of Health grants for a number of years, including the principal investigator of a program project to study lung inflammation and a recipient of a previous NIH MERIT Award, served on National Institute of Health peer review study sections, organized numerous international conferences on inflammation, and is an associate editor for various professional scientific journals. He is the present co-chair of the Board of Scientific Counselors for the NIAID-NIH.
He received his Ph.D. from the University of Kansas in microbiology and served his postdoctoral fellowship at the University of Connecticut Health Center. He joined the University of Michigan Medical School faculty in 1980, and served as senior associate dean for research in the Medical School since 2007.
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Center MemberCenter for Integrative Research in Critical Care
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Sonobe S, Kitabatake M, Hara A, Konda M, Ouji-Sageshima N, Terada-Ikeda C, Furukawa R, Imakita N, Oda A, Takeda M, Takamura S, Inoue S, Kunkel SL, Kawaguchi M, Ito T. Shock, 2023 Jul 1; 60 (1): 137 - 145.Journal ArticleTHE CRITICAL ROLE OF THE HISTONE MODIFICATION ENZYME SETDB2 IN THE PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME.
DOI:10.1097/SHK.0000000000002145 PMID: 37195726 -
Mangum KD, Joshi AD, Melvin WJ, Mazumder P, Erturk A, Wolf S, Barrett EC, Moon JY, Obi A, Kunkel SL, Moore BB, Gallagher K. The Journal of Immunology, 2023 May 1; 210 (1_Supplement): 229.07 - 229.07.Proceeding / Abstract / PosterThe histone methyltransferase Whsc1 regulates TGFβ-driven macrophage to myofibroblast transition
DOI:10.4049/jimmunol.210.supp.229.07 -
Kimura S, Dupee Z, Lima F, Allen R, Kazmi S, Diodati N, Lukacs NW, Kunkel SL, Schaller M. Immunohorizons, 2023 Feb 1; 7 (2): 168 - 176.Journal ArticleJagged-1 Reduces Th2 Inflammation and Memory Cell Expansion in Allergic Airway Disease.
DOI:10.4049/immunohorizons.2300001 PMID: 36729482 -
Audu CO, Melvin WJ, Joshi AD, Wolf SJ, Moon JY, Davis FM, Barrett EC, Mangum KD, Deng H, Xing X, Wasikowski R, Tsoi LC, Sharma SB, Bauer TM, Shadiow J, Corriere MA, Obi AT, Kunkel SL, Levi B, Moore BB, Gudjonsson JE, Smith AM, Gallagher KA. Cell Mol Immunol, 2022 Nov; 19 (11): 1251 - 1262.Journal ArticleMacrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair.
DOI:10.1038/s41423-022-00919-5 PMID: 36127466 -
Bermick JR, Issuree P, denDekker A, Gallagher KA, Santillan D, Kunkel S, Lukacs N, Schaller M. Immunol Cell Biol, 2022 Aug; 100 (7): 562 - 579.Journal ArticleDifferences in H3K4me3 and chromatin accessibility contribute to altered T-cell receptor signaling in neonatal naïve CD4 T cells.
DOI:10.1111/imcb.12561 PMID: 35608955 -
Wolf SJ, Audu CO, Joshi A, denDekker A, Melvin WJ, Davis FM, Xing X, Wasikowski R, Tsoi LC, Kunkel SL, Gudjonsson JE, O'Riordan MX, Kahlenberg JM, Gallagher KA. JCI Insight, 2022 May 9; 7 (9):Journal ArticleIFN-κ is critical for normal wound repair and is decreased in diabetic wounds.
DOI:10.1172/jci.insight.152765 PMID: 35358091 -
Strieter RM, Standiford TJ, Rolfe MW, Kunkel SL. Cytokines of the Lung, 281 - 305.ChapterInterleukin-8
DOI:10.1201/9781003066927-10 -
Davis FM, Tsoi LC, Ma F, Wasikowski R, Moore BB, Kunkel SL, Gudjonsson JE, Gallagher KA. Ann Surg, 2022 Sep 1; 276 (3): 511 - 521.Journal ArticleSingle-cell Transcriptomics Reveals Dynamic Role of Smooth Muscle Cells and Enrichment of Immune Cell Subsets in Human Abdominal Aortic Aneurysms.
DOI:10.1097/SLA.0000000000005551 PMID: 35762613