Sami N Malek, MD
Maria Reinhardt DeCesare Research Professor of Blood Cancers and Bone Marrow Transplantation and Professor of Internal Medicine
[email protected]

Available to mentor
Sami N Malek, MD
Professor
  • Center Memberships
  • Research Overview
  • Recent Publications
    • Center Memberships
    • Center Member
      Rogel Cancer Center
    Research Overview

    CLL genetics
    CLL biomarkers
    Targeted therapy development
    MDS/AML genetics
    Lymphoma genetics

    Recent Publications See All Publications
    • Journal Article
      Aberrant BCAT1 expression augments MTOR activity and accelerates disease progression in chronic lymphocytic leukemia.
      Shao Q, Wykretowicz J, Hu N, Bedi K, Rizk M, Malek IA, Kumar S, Lombard DB, Shedden K, Scott D, Malek SN. Leukemia, 2024 Oct 25; DOI:10.1038/s41375-024-02448-8
      PMID: 39455853
    • Journal Article
      Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency.
      Wang F, Yang Y, Boudagh G, Eskelinen E-L, Klionsky DJ, Malek SN. Autophagy, 2022 Aug; 18 (8): 1982 - 2000. DOI:10.1080/15548627.2022.2050663
      PMID: 35287545
    • Journal Article
      Mutations in V-ATPase in follicular lymphoma activate autophagic flux creating a targetable dependency.
      Wang F, Yang Y, Klionsky DJ, Malek SN. Autophagy, 2023 Feb; 19 (2): 716 - 719. DOI:10.1080/15548627.2022.2071382
      PMID: 35482846
    • Proceeding / Abstract / Poster
      Abstract 1939: Follicular Lymphoma-associated mutations in the V-ATPase assembly factor VMA21 activate autophagic flux
      Wang F, Yang Y, Boudagh G, Eskelinen E-L, Klionsky DJ, Malek SN. Cancer Research, 2021 Jul 1; 81 (13_Supplement): 1939 - 1939. DOI:10.1158/1538-7445.am2021-1939
    • Presentation
      The combination of venetoclax, lenalidomide, and rituximab in patients with newly diagnosed mantle cell lymphoma induces high response rates and MRD undetectability.
      2021 Jun 24;
    • Journal Article
      Follicular Lymphoma-associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation.
      Hu N, Wang F, Sun T, Xu Z, Zhang J, Bernard D, Xu S, Wang S, Kaminski M, Devata S, Phillips T, Malek SN. Clin Cancer Res, 2021 Apr 15; 27 (8): 2301 - 2313. DOI:10.1158/1078-0432.CCR-20-3741
      PMID: 33419778
    • Journal Article
      Targeted Therapies for Follicular Lymphoma.
      Girard J, Karimi Y, Carty S, Wilcox R, Kaminiski M, Malek S, Phillips T. Curr Hematol Malig Rep, 2021 Feb; 16 (1): 25 - 31. DOI:10.1007/s11899-021-00614-8
      PMID: 33754292
    • Journal Article
      Therapeutic targeting of TP53-mutated acute myeloid leukemia by inhibiting HIF-1α with echinomycin.
      Wang Y, Liu Y, Bailey C, Zhang H, He M, Sun D, Zhang P, Parkin B, Baer MR, Zheng P, Malek SN, Liu Y. Oncogene, 2020 Apr; 39 (14): 3015 - 3027. DOI:10.1038/s41388-020-1201-z
      PMID: 32060420