Research Investigator
Human Genetics
[email protected]
Available to mentor
Wenxi Yu
Research Investigator
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Yu W, Hill SF, Huang Y, Zhu L, Demetriou Y, Ziobro J, Reger F, Jia X, Mattis J, Meisler MH. Ann Neurol, 2024 Nov; 96 (5): 958 - 969.Journal ArticleAllele-Specific Editing of a Dominant SCN8A Epilepsy Variant Protects against Seizures and Lethality in a Murine Model.
DOI:10.1002/ana.27053 PMID: 39158034 -
Yu W, Hill SF, Zhu L, Demetriou Y, Reger F, Mattis J, Meisler MH. Neurobiol Dis, 2024 Sep; 199: 106591Journal ArticleDentate gyrus granule cells are a locus of pathology in Scn8a developmental encephalopathy.
DOI:10.1016/j.nbd.2024.106591 PMID: 38969233 -
Hill SF, Yu W, Ziobro J, Chalasani S, Reger F, Meisler MH. Ann Neurol, 2024 Apr; 95 (4): 754 - 759.Journal ArticleLong-Term Downregulation of the Sodium Channel Gene Scn8a Is Therapeutic in Mouse Models of SCN8A Epilepsy.
DOI:10.1002/ana.26861 PMID: 38113311 -
Thompson JA, Miralles RM, Wengert ER, Wagley PK, Yu W, Wenker IC, Patel MK. Epilepsia Open, 2022 Jun; 7 (2): 280 - 292.Journal ArticleAstrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy.
DOI:10.1002/epi4.12564 PMID: 34826216 -
Yu W, Mulligan MK, Williams RW, Meisler MH. HGG Adv, 2022 Jan 13; 3 (1): 100064Journal ArticleCorrection of the hypomorphic Gabra2 splice site variant in mouse strain C57BL/6J modifies the severity of Scn8a encephalopathy.
DOI:10.1016/j.xhgg.2021.100064 PMID: 35047853 -
Yu W, Smolen CE, Hill SF, Meisler MH. Hum Mol Genet, 2021 May 29; 30 (10): 902 - 907.Journal ArticleSpontaneous seizures and elevated seizure susceptibility in response to somatic mutation of sodium channel Scn8a in the mouse.
DOI:10.1093/hmg/ddab092 PMID: 33822038 -
Meisler MH, Hill SF, Yu W. Nat Rev Neurosci, 2021 Apr; 22 (4): 256Journal ArticleAuthor Correction: Sodium channelopathies in neurodevelopmental disorders.
DOI:10.1038/s41583-021-00449-5 PMID: 33686192 -
Meisler MH, Hill SF, Yu W. Nat Rev Neurosci, 2021 Mar; 22 (3): 152 - 166.Journal ArticleSodium channelopathies in neurodevelopmental disorders.
DOI:10.1038/s41583-020-00418-4 PMID: 33531663
Department News
Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
Department News
Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
